I-World Arthritis Day umcimbi womhlaba wonke wokuqwashisa ngezempilo ohlelwa minyaka yonke ngomhla ziyi-12 kuMfumfu ukuze kuqwashiswe ngezifo ezithinta izicubu nemisipha, umthelela wazo empilweni yomuntu kanye nokufundisa abantu izimpawu nezindlela zokuzivikela kanye nomhlahlandlela wokuxilongwa kusenesikhathi ukuze ubhekane nanoma yiziphi ezinye izinkinga. .
Ukubaluleka Kosuku Lomhlaba Lwe-Arthritis (WAD)
I-arthritis iwukuvuvukala kwamalunga, okuthinta izicubu zamalunga ezizungeze ilunga, nezinye izicubu ezixhumene, okubangela ubuhlungu nokuqina kwamalunga.Kukhona izinhlobo ezingaphezu kwe-100 zesifo samathambo, kodwa ezivame kakhulu i-osteoarthritis kanye nesifo samathambo.Ngenxa yokuntuleka kokuqwashisa nokusekelwa, isifo sokuqaqamba kwamalunga kanye nesimo esihlobene naso kuye kwakhubaza ukuphila okuningi emhlabeni jikelele.Akukho ukwelashwa okuqondile kwesifo samathambo, indlela yokwelashwa iyehluka kuye ngezinhlobo, ngakho-ke kubalulekile ukuqonda uphawu nezimpawu bese uxilonga kusenesikhathi ukuze uthole ukwelashwa okufanele.
Uhlobo Oluvame Kakhulu Lwe-Arthritis
Izinhlobo ezivame kakhulu zihlanganisa i-osteoarthritis (OA), i-rheumatoid arthritis (RA), i-psoriatic arthritis (PsA), i-fibromyalgia kanye ne-gout.I-arthritis kanye nezifo ezihlobene nazo zingabangela ubuhlungu obuqeda amandla, obushintsha ukuphila ngezindlela ezahlukene.
I-arthritis ye-Rheumatoid (RA) ingenye yezifo ezihlangene ezivuthayo ezivame kakhulu, ezivame kakhulu kwabesifazane abaneminyaka ephakathi.Ibonakaliswa ikakhulukazi njenge-chronic, symmetrical, i-polyarthritis eqhubekayo.Ngaphezu kokuthinta amalunga, kunezibonakaliso eziningi ezengeziwe, njengesikhumba, amehlo, inhliziyo, amaphaphu, uhlelo lwegazi, njll.
Ukuvama kwe-RA kungu-0.5-1%, kanti isilinganiso sowesifazane nendoda singu-3:1.Iphakama ngokuphindwe ka-4 kuya kwezi-5 kwabesifazane abaneminyaka engaphansi kwengama-50, kodwa ngemva kweminyaka engama-60 isilinganiso siba cishe ku-2 kuya ku-1.Abantu abane-rheumatoid arthritis ngokuvamile banezinga eliphezulu le-C-reactive protein (CRP), elingase libonise ukuba khona kwenqubo yokuvuvukala emzimbeni.Okunye ukuhlolwa kwegazi okuvamile kubheka amasosha omzimba e-rheumatoid factor (RF) kanye ne-anti-cyclic citrullinated peptide (anti-CCP).
RA(I-Rheumatoid arthritis)
I-Rheumatoid arthritis yisifo esingapheli sokuvuvukala esingathinta ngaphezu kwamalunga akho nje.Kwabanye abantu, lesi simo singalimaza izinhlobonhlobo zezinhlelo zomzimba, okuhlanganisa isikhumba, amehlo, amaphaphu, inhliziyo nemithambo yegazi.
I-autoimmune disorder, i-rheumatoid arthritis yenzeka lapho amasosha akho omzimba ehlasela izicubu zomzimba wakho ngephutha.
Ngokungafani nomonakalo ogugayo we-osteoarthritis, isifo samathambo sithinta ulwelwesi lwamalunga akho, sibangele ukuvuvukala okubuhlungu okungagcina kubangele ukuguguleka kwamathambo nokukhubazeka kwamalunga.
I-Anti-CCP Anti-Cyclic Citrullinated Peptide Antibody
I-Anti-cyclic citrullinated peptide antibody (Anti-CCP): Iyingxenye ye-polypeptide ye-cyclic polyguanidine protein futhi ikakhulukazi i-IgG-type antibody.Amasosha omzimba e-anti-cyclic citrullinated peptide akhiqizwa ngokuzenzakalelayo ama-lymphocyte e-B eziguli ezine-rheumatoid arthritis (RA), kuyilapho ama-lymphocyte e-B eziguli ezinezinye izifo kanye nabantu abavamile angazikhiqizi ngokuzenzakalelayo amasosha omzimba e-anti-cyclic citrullinated peptide.Ngakho-ke, inokuzwela okuphezulu kanye nokucaciswa kwe-arthritis ye-rheumatoid, futhi iyinkomba ecacile kakhulu yokuxilongwa kusenesikhathi kwe-rheumatoid arthritis.
I-Anti-CCP (Anti-cyclic citrullinated peptides) iwuhlobo lwama-autoantibody: i-antibody esebenza ngokumelene namasosha omzimba avamile.I-Anti-CCP ivame ukukhiqizwa uma une-arthritis ye-rheumatoid.Lawa ma-autoantibodies aqala ukukhomba futhi ahlasele izicubu ezinempilo.
Izinkomba zokuxilonga zakuqala ze-rheumatoid arthritis: ama-anti-cyclic citrullinated antibodies avela eminyakeni engu-1-10 ngaphambi kokubonakaliswa komtholampilo kwe-arthritis ye-rheumatoid, efanelekile ukuhlolwa ngokomzimba kwabantu abanempilo kanye nokuxilongwa kusenesikhathi kwamaqembu asengozini enkulu.Okwamanje,kukholakala ukuthi ukuzwela kwe-anti-cyclic citrullinated peptide antibodies ekuxilongweni kwe-rheumatoid arthritis yi-50% kuya ku-78%, ukucaciswa ku-96%, futhi izinga elihle leziguli zakuqala lingafinyelela ku-80%.
AehheimpiloAni-I-CCP Pumzila
I-Aehealth Anti-CCP (Anti-cyclic Citrullinated Peptide Antibody) Ukuhlola Okusheshayo Kwesilinganiso kusebenzisa indlela ye-Immunofluorescence Assay.
Ibanga lomugqa lokutholwa kwekhithi ye-Anti-CCP ngu-10～500 U/mL;i-coefficient yokuhlobana komugqa phakathi kokugxilisa kwethiyori nokugxilisa ingqondo okulinganiselwe ingafinyelela ku-r≥0.990.Isetshenziswa nokuhlaziywa kwe-Aehealth Lamuno X immunofluorescence ukuze kuphelezelwe ukuxilongwa kusenesikhathi kanye nokuhlolwa kokwelashwa kweziguli ezinesifo samathambo.
Amasosha omzimba e-Anti-CCP ahlotshaniswa nemingcele yomsebenzi we-RA.
Amasosha omzimba e-Anti-CCP abikezela umonakalo we-RA.
Isikhathi sokuthumela: Oct-12-2022